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Limitations and Considerations BMI cutoff used is in between the typical cutoffs for overweight and obese Limited generalizability given that the majority of patients included were Caucasian, with only 12.5% African American male predominant population studied, with only 27.7% females It remains to be demonstrated if treatment with semaglutide has a cardioprotective and preventative benefit in patients who do not have pre-existing cardiovascular disease PowellWiley TM, Poirier P, Burke LE, et al
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At this point, Semaglutide is usually at its full therapeutic dose, and results can become even more noticeable if paired with nutrition guidance and physical activity
doi: 10.1056/NEJMoa1008862 3 HolmanRRPaulSKBethelMAMatthewsDRNeilHA
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